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1-Boc-Azetidine-3-yl-methanol

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1-Boc-Azetidine-3-yl-methanol Basic information

Product Name:
1-Boc-Azetidine-3-yl-methanol
Synonyms:
  • 1-Boc-3-azetidineMethanol, 95%
  • Boc-Azetidin-3-ylMethanol
  • 1-(tert-Butoxycarbonyl)-3-azetidineMethanol
  • 1-Azetidinecarboxylic acid, 3-(hydroxyMethyl)-, 1,1-diMethylethyl ester
  • EOS-61767
  • 1-Boc-3-(hydroxyMethyl)azetidine, 97+%
  • TERT-BUTYL 3-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE
  • 3-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS:
142253-56-3
MF:
C9H17NO3
MW:
187.24
EINECS:
218-697-7
Mol File:
142253-56-3.mol
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1-Boc-Azetidine-3-yl-methanol Chemical Properties

Melting point:
55 °C
Boiling point:
268-273℃
Density 
1.115
Flash point:
117°(243°F)
storage temp. 
2-8°C
solubility 
Soluble in Dimethyl sulfoxide (DMSO).
pka
14.82±0.10(Predicted)
form 
powder to lump
color 
White to Almost white
InChI
InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-4-7(5-10)6-11/h7,11H,4-6H2,1-3H3
InChIKey
HXRDRJKAEYHOBB-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(CO)C1
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-26-37-60
TSCA 
No
HazardClass 
IRRITANT
HS Code 
29339900
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1-Boc-Azetidine-3-yl-methanol Usage And Synthesis

Description

1-Boc-Azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Chemical Properties

Clear colorless liquid

Uses

It is an intermediate in organic syntheses

1-Boc-Azetidine-3-yl-methanol Preparation Products And Raw materials

Raw materials

Sodium hydroxideHydrochloric acidMethanolTetrahydrofuranDichloromethaneThionyl chlorideTolueneAmmoniaLithium aluminium hydridePalladiumAcetonitrileFormaldehydeSodium borohydrideDi-tert-butyl dicarbonateDiethyl malonateTrifluoroacetic anhydrideBenzylamineEthyldiisopropylamineBoron trifluoride etherate

1-Boc-Azetidine-3-yl-methanolSupplier

PharmaBlock Sciences (Nanjing),Inc. Gold
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025-86918202 4000255188
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
Chembest Research Laboratories Limited
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+86-21-20908456
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Alfa Aesar
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400-6106006
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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Sales-CN@TCIchemicals.com
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