Basic information Safety Supplier Related

7-Hydroxygranisetron

Basic information Safety Supplier Related

7-Hydroxygranisetron Basic information

Product Name:
7-Hydroxygranisetron
Synonyms:
  • 1H-INDAZOL-3-CARBONIC ACID
  • 1H-INDAZOLE-3-CARBOXYLIC ACID
  • 1H-INDAZOLE-3-CARBONIC ACID
  • AKOS BB-9978
  • 3-INDAZOLECARBOXYLIC ACID
  • 3-CARBOXYINDAZOLE
  • ndazole-3-carboxylic acid
  • INDAZOLE-3-CARBOXYLIC ACID
CAS:
4498-67-3
MF:
C8H6N2O2
MW:
162.15
EINECS:
224-794-5
Product Categories:
  • Indoles and derivatives
  • pharmacetical
  • Acids and Derivatives
  • Heterocycles
  • Carboxylic Acids
  • Organic acids
  • PHARMACEUTICAL INTERMEDIATES
  • (intermediate of granisetron)
  • Indazoles
  • Indole Derivatives
  • Carboxylic Acids
  • Fused Ring Systems
  • Building Blocks
  • Heterocyclic Building Blocks
Mol File:
4498-67-3.mol
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7-Hydroxygranisetron Chemical Properties

Melting point:
266-270 °C (dec.)
Boiling point:
443.7±18.0 °C(Predicted)
Density 
1.506±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
3.03±0.10(Predicted)
form 
powder
color 
beige
BRN 
6354
InChI
InChI=1S/C8H6N2O2/c11-8(12)7-5-3-1-2-4-6(5)9-10-7/h1-4H,(H,9,10)(H,11,12)
InChIKey
BHXVYTQDWMQVBI-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)C(C(O)=O)=N1
CAS DataBase Reference
4498-67-3(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36-36/37/38
Safety Statements 
26-36/37/39-22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900

MSDS

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7-Hydroxygranisetron Usage And Synthesis

Chemical Properties

yellow crystal

Uses

Indazole-3-carboxylic acid may be used in the synthesis of the following:

  • N-(8-methyl-azabicyclo[3.2.11]oct-3-yl)-1H-indazole-3-carboxamide
  • N-(1- benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide
  • 1H-indazole-3-carboxamide

Uses

Indazole-3-carboxylic acid is indole derivatives useful in treatment of pain and inflammation

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 531, 1989 DOI: 10.1002/jhet.5570260251

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