Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride Chemical Properties

Melting point:

188°C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Almost white

Safety Information

HS Code 

2922498590

Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

Methyl cis-4-aminocyclohexanecarboxylate HCl

Synthesis

Step A: Preparation of methyl trans-4-aminocyclohexanecarboxylate hydrochloride. Trans-4-aminocyclohexanecarboxylic acid (200 mg, 1.40 mmol) was suspended in methanol (5.5 mL) and cooled to -10 °C. Thionyl chloride (204 μL, 2.79 mmol) was added dropwise under stirring and the reaction mixture was stirred at -10 °C for 15 min. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 15 min, after which it was heated to reflux for 1 hr. After completion of the reaction, the reaction was cooled to room temperature and the reaction mixture was concentrated under reduced pressure to afford the white solid product methyl trans-4-aminocyclohexanecarboxylate hydrochloride (260 mg, 96.1% yield). Mass spectral analysis (APCI) showed m/z = 158.0 ([M+H]+).

References

[1] Patent: WO2011/6074, 2011, A1. Location in patent: Page/Page column 95

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