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2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile

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2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Basic information

Product Name:
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
Synonyms:
  • 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
  • Erlotinib Hydrochloride iMpurity 23
  • 2-((4-chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
  • Benzonitrile, 2-amino-4,5-bis(2-methoxyethoxy)-
  • Erlotinib Impurity 134
CAS:
950596-58-4
MF:
C13H18N2O4
MW:
266.29
EINECS:
1308068-626-2
Mol File:
950596-58-4.mol
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2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Chemical Properties

Melting point:
73-77 °C
Boiling point:
445.5±45.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
1.85±0.10(Predicted)
color 
Pale Beige to Beige
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2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Usage And Synthesis

Uses

2-((4-Chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol is an impurity if Erlotinib (E625008) a EGFR-targeted drug in the treatment of non-small cell lung cancer.

Uses

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.

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