2-Chloro-4-ethoxy-6-methyl-pyrimidine Chemical Properties

Melting point:

70-73℃

Boiling point:

282℃

Density 

1.193

Flash point:

124℃

storage temp. 

Storage temp. 2-8°C

pka

0.76±0.30(Predicted)

Appearance

White to off-white Solid

Safety Information

HazardClass 

IRRITANT

HS Code 

2933599590

2-Chloro-4-ethoxy-6-methyl-pyrimidine Usage And Synthesis

Uses

2-Chloro-4-ethoxy-6-methylpyrimidine is a reactant/starting material in the preparation of azolylpyrimidines as cytoprotective antiulcer agents.

Synthesis

General procedure: 2,4-dichloro-6-methylpyrimidine (3.0 g, 18.4 mmol), cesium carbonate (Cs2CO3, 6.6 g, 20.2 mmol) and ethanol (EtOH, 46 mL) were added to a reaction flask, and the mixture was stirred under reflux conditions for 48 hours. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was purified by column chromatography to afford the target product 2-chloro-4-ethoxy-6-methylpyrimidine (1.88 g, 59% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ6.47 (1H, s), 4.41 (2H, q), 2.42 (3H, s), 1.39 (3H, t).

References

[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0476
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5206 - 5220
[3] Patent: WO2016/133959, 2016, A1. Location in patent: Page/Page column 46; 47

2-Chloro-4-ethoxy-6-methyl-pyrimidine(37482-64-7)Related Product Information

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