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Vantas

Basic information Safety Supplier Related

Vantas Basic information

Product Name:
Vantas
Synonyms:
  • (Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
  • Supprelin la
  • Vantas
  • Histrelin acetate, >=98%
  • Histrelin?Acetate impurity
  • Vantas USP/EP/BP
  • Histrelin Acetate(acetate)
  • (Des-Gly??,D-His(Bzl)?,Pro-NHEt?)-LHRH acetate salt
CAS:
220810-26-4
MF:
C66H86N18O12
MW:
1323.52
Mol File:
220810-26-4.mol
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Vantas Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to off-white
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Vantas Usage And Synthesis

Description

Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.

Definition

ChEBI: An acetate salt obtained by combining histrelin with acetic acid. The amount of acetic acid present can vary and a variable amount of water may be present. Histrelin acetate is used as a subcutaneous hydrogel implant for the treatment of prostate cancer an for the suppression of gonadal sex hormone production in children with central precocious puberty.

VantasSupplier

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Shenzhen JYMed Technology Co., Ltd.
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Wuhan Senwayer Century Chemical Co.,Ltd
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027-86652399 13627115097;
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