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Nsc670365

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Nsc670365 Basic information

Product Name:
Nsc670365
Synonyms:
  • (+/-)-trans-Ketone
  • (1)-12-Oxocalanolide a
  • 12-Oxocalanolide
  • 151005-67-3 (Deleted)
  • trans-10,11-Dihydro-6,6,10,11-tetramethyl-4-propyl-2H,6H,12H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2,12-dione
  • 2H,6H,12H-Benzo[1,2-B:3,4-B':5,6-B'']tripyran-2,12-dione, 10,11-dihydro-6,6,10,11-tetramethyl-4-propyl-, (10R,11R)-rel-
  • Aids051610
  • Aids-051610
CAS:
161753-49-7
MF:
C22H24O5
MW:
368.42
Mol File:
161753-49-7.mol
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Nsc670365 Chemical Properties

Boiling point:
546.7±50.0 °C(Predicted)
Density 
1.176±0.06 g/cm3(Predicted)
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Nsc670365 Usage And Synthesis

Uses

12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC50 and EC50 of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide[1].

IC 50

HIV-1

References

[1] Zembower DE, et al. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C). J Med Chem. 1997;40(6):1005-1017. DOI:10.1021/jm960355m

Nsc670365Supplier

BioBioPha Co., Ltd.
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Nanjing Dasf Biotechnology Co., Ltd.
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