Sancycline hydrochloride Chemical Properties

Melting point:

224-2280C (dec.)

storage temp. 

-20°C Freezer

solubility 

DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.15 mg/mL; Ethanol: 5mg/mL

form 

A crystalline solid

color 

White to off-white

Sancycline hydrochloride Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

Sancycline Hydrochloride (Minocycline EP Impurity B) is a semi-synthetic antibiotic related to Tetracycline.

Uses

Sancycline hydrochloride is the hydrochloride salt of a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

IC 50

Tetracycline

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