2-Amino-3-bromo-6-chloropyrazine Chemical Properties

Boiling point:

299.5±35.0 °C(Predicted)

Density 

1.960

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.05±0.10(Predicted)

Safety Information

HS Code 

2933998090

2-Amino-3-bromo-6-chloropyrazine Usage And Synthesis

Uses

2-amino-3-bromo-6-chloropyrazine has essential applications in the pharmaceutical industry and is an important intermediate for synthesizing an anti-tumor medicament SHP2 inhibitor.

Preparation

Currently, in thepreparing 2-amino-3-bromo-6-chloropyrazine, the 2-amino-6-chloropyrazine is mainly obtained by a one-step bromination reaction. According to the method, bromine is mainly positioned at an amino para position due to the activation effect of amino; generated byproducts are mainly 2-bromo-3-chloro-5-aminopyrazine and partial dibromo byproduct 2-amino-3, 5-dibromo-6-chloropyrazine, the product 2-amino-3-bromo-6-chloro is less, the yield is low. A process for preparing 2-amino-3-bromo-6-chloropyrazine uses 3-aminopyrazine-2-carboxylate as raw material and includes such steps as chlorination, diazotization bromination, ester hydrolysis, carboxyl rearrangement and removing tert-butyloxycarbonyl.

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