1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Chemical Properties

Melting point:

266 °C(dec.)

storage temp. 

2-8°C

solubility 

DMSO: ≥10mg/mL

form 

powder

color 

yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

InChI

1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3

InChIKey

VVZNWYXIOADGSW-UHFFFAOYSA-N

SMILES

COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50

Safety Statements 

61

WGK Germany 

3

HS Code 

2933.99.8290

Storage Class

11 - Combustible Solids

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Usage And Synthesis

Description

ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2

Uses

ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.

General Description

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

Biochem/physiol Actions

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

storage

+4°C

References

[1] TOMOYUKI MIYABAYASHI. Indole derivatives sustain embryonic stem cell self-renewal in long-term culture.[J]. Bioscience, Biotechnology, and Biochemistry, 2008, 72 5: 1242-1248. DOI:10.1271/bbb.70717
[2] KOUICHI HASEGAWA. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.[J]. Stem Cells Translational Medicine, 2012, 1 1: 18-28. DOI:10.5966/sctm.2011-0033

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