ARRY-424704, ARRY-704
ARRY-424704, ARRY-704 Basic information
- Product Name:
- ARRY-424704, ARRY-704
- Synonyms:
-
- ARRY-424704, ARRY-704
- AZD8330
- 2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
- ARRY424704
- ARRY-424704
- ARRY704
- ARRY-704
- AZD8330/ARRY-424704/arry-704/AZD8330/AZD-8330
- CAS:
- 869357-68-6
- MF:
- C16H17FIN3O4
- MW:
- 461.23
- EINECS:
- 642-441-7
- Product Categories:
-
- Inhibitors
- MAPK
- Mol File:
- 869357-68-6.mol
ARRY-424704, ARRY-704 Chemical Properties
- Density
- 1.732
- storage temp.
- Store at -20°C
- solubility
- ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH
- form
- solid
- pka
- 14.31±0.10(Predicted)
- color
- Off-white to pink
ARRY-424704, ARRY-704 Usage And Synthesis
Description
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
Uses
AZD8330 is an orally active and selective MEK inhibitor.
Definition
ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
target
ERK phosphorylation
References
1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.
ARRY-424704, ARRY-704Supplier
- Tel
- sales@boylechem.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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