ChemicalBook > Product Catalog > Natural Products > Flavonoids > 5-Hydroxy-3',4',7-trimethoxyflavone
5-Hydroxy-3',4',7-trimethoxyflavone
5-Hydroxy-3',4',7-trimethoxyflavone Basic information
- Product Name:
- 5-Hydroxy-3',4',7-trimethoxyflavone
- Synonyms:
-
- 4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5-hydroxy-7-Methoxy-
- Gonzalitosin I
- Luteolin 7,3',4'-trimethyl ether
- 2-(3,4-DiMethoxyphenyl)-5-hydroxy-7-Methoxy-4H-chroMen-4-one
- 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone)
- 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one
- Rutoside Trihydrate Impurity 12
- COX,TNFR,7,3',4'TriOmethylluteolin,lipopolysaccharide,Tumor Necrosis Factor Receptor,Inflammation-related diseases,pro-inflammatory cytokines,RAW 264.7 macrophage,Interleukin Related,inhibit,TNF Receptor,Cyclooxygenase,7,3',4' Tri O methylluteolin,Inhibitor
- CAS:
- 29080-58-8
- MF:
- C18H16O6
- MW:
- 328.32
- Mol File:
- 29080-58-8.mol
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5-Hydroxy-3',4',7-trimethoxyflavone Chemical Properties
- Melting point:
- 163 °C
- Boiling point:
- 536.3±50.0 °C(Predicted)
- Density
- 1.314±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- pka
- 6.32±0.40(Predicted)
- form
- Solid
- color
- White to yellow
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5-Hydroxy-3',4',7-trimethoxyflavone Usage And Synthesis
Uses
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2[1].
IC 50
IL-6; IL-1β; COX-2
References
[1] Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.
5-Hydroxy-3',4',7-trimethoxyflavoneSupplier
BioBioPha Co., Ltd.
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- 0871-65217109 13211707573;
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Chengdu Biopurify Phytochemicals Ltd.
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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- 0510-85629785 18013409632
- sales@reading-chemicals.com
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5-Hydroxy-3',4',7-trimethoxyflavone(29080-58-8)Related Product Information
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- MOSLOFLAVONE
- hydroxygenkwanin
- PONCIRIN
- Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)
- 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one