Pepluanin A
Pepluanin A Basic information
- Product Name:
- Pepluanin A
- Synonyms:
-
- Pepluanin A
- 3-Pyridinecarboxylic acid, (2R,3R,3aS,4R,6S,7S,8S,10E,12S,13S,13aR)-2,4,6,7,13-pentakis(acetyloxy)-3-(benzoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-13a-hydroxy-2,9,9,12-tetramethyl-5-methylene-1H-cyclopentacyclododecen-8-yl ester
- CAS:
- 670257-89-3
- MF:
- C43H51NO15
- MW:
- 821.86
- Mol File:
- 670257-89-3.mol
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Pepluanin A Usage And Synthesis
Uses
Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport[1]
References
[1] Corea G, et al. Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A. J Med Chem. 2004;47(4):988-992. DOI:10.1021/jm030951y
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