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Tetrahydroamentoflavone

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Tetrahydroamentoflavone Basic information

Product Name:
Tetrahydroamentoflavone
Synonyms:
  • Tetrahydroamentoflavone
  • Amentoflavanone
  • 4H-1-Benzopyran-4-one, 8-[5-[(2S)-3,4-dihydro-5,7-dihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2-hydroxyphenyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2S)-
  • (2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
CAS:
48236-96-0
MF:
C30H22O10
MW:
542.49
Mol File:
48236-96-0.mol
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Tetrahydroamentoflavone Chemical Properties

Boiling point:
932.8±65.0 °C(Predicted)
Density 
1.584±0.06 g/cm3(Predicted)
pka
6.87±0.40(Predicted)
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Tetrahydroamentoflavone Usage And Synthesis

Uses

Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout[1].

References

[1] Ranjith Arimboor, et al. Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase. J Ethnopharmacol. 2011 Feb 16;133(3):1117-20. DOI:10.1016/j.jep.2010.10.027

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