Methyl 1-acetyl-2-oxoindoline-6-carboxylate Chemical Properties

Boiling point:

489.5±45.0 °C(Predicted)

Density 

1.330

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

-1.94±0.20(Predicted)

form 

Solid

color 

Off-White to Pale Red

Methyl 1-acetyl-2-oxoindoline-6-carboxylate Usage And Synthesis

Uses

Methyl 1-Acetyl-2-oxoindoline-6-carboxylate is a reagent used in the preparation of Nintedanib (N478290), an angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

Methyl 1-acetyl-2-oxoindoline-6-carboxylate(676326-36-6)Related Product Information

• BIBF 1202
• 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate
• N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
• 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER
• N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide
• 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
• (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
• (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
• 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
• METHYL OXINDOLE-7-CARBOXYLATE
• 1-Chloro-4-(trimethoxymethyl)benzene
• N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
• P-ANISALDEHYDE DIMETHYL ACETAL
• Methyl oxindole-5-carboxylate
• N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
• Nintedanib
• Methyl 4-chloro-3-nitrobenzoate
• 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE