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Y27632 (hydrochloride)

Basic information Safety Supplier Related

Y27632 (hydrochloride) Basic information

Product Name:
Y27632 (hydrochloride)
Synonyms:
  • Y-27632; Y27632; Y 27632
  • CS-1919
  • Y-27632; Y27632; Y 27632;Y 27632 DIHYDROCHLORIDE;Y27632 DIHYDROCHLORIDE
  • Y-27632 dihydrochloride, 98.5%, a selective ROCK1 (p160ROCK) inhibitor
  • (R)-4-(1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
  • Y-27632 DIHYDROCHLORIDE;ROCK INHIBITOR
  • Y-27632 dihydrochloride, >=98%
  • trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride Y 27632 dihydrochloride
CAS:
129830-38-2
MF:
C14H23Cl2N3O
MW:
320.25792
EINECS:
813-428-5
Product Categories:
  • Inhibitors
  • APIs
Mol File:
129830-38-2.mol
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Y27632 (hydrochloride) Chemical Properties

Melting point:
258℃
storage temp. 
2-8°C
solubility 
H2O: soluble14mg/mL
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
HS Code 
29333990
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Y27632 (hydrochloride) Usage And Synthesis

Description

Y-27632 dihydrochloride (129830-38-2) is a specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Y-27632 dihydrochloride significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential.3

Uses

A cell permeable inhibitor of ROCK-1 and ROCK-2

Uses

Y-27632 dihydrochloride has been used:

  • as a medium supplement in pancreatic ductal adenocarcinoma organoid culture
  • in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells
  • in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)

General Description

Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.

Biochem/physiol Actions

Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

References

1) Ishizaki et al. (2000), Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases; Mol. Pharmacol., 57 976 2) Gauthaman et al. (2010), Effects of ROCK Inhibitor Y-27632 on Normal and Variant Human Embryonic Stem Cells (hESCs) In Vitro: Its Benefits in hESC Expansion; Stem Cell Rev., 6 86 3) Li et al. (2008), The ROCK Inhibitor Y-27632 enhances the Survival Rate of Human Embryonic Stem Cells Following Cryopreservation; Stem Cells Dev., 17 1079 4) Morel et al. (2018), Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature Y-27632; Mol. Cell. Proteomics, 17 1750 [Focus Citation] 5) Yamazaki et al. (2020) Chromatin condensation retains the osteogenic transcription factor, RUNX2, in the nucleus of human mesenchymal stem cells; J. Biomechanical Science and Engineering 15? 1 [Focus Citation]

Y27632 (hydrochloride)Supplier

Chemleader Biomedical Co., Limited. Gold
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Shanghai Lollane Biological Technology Co.,Ltd. Gold
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Shanghai Tube Pharmaceutical Co., Ltd. Gold
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Shanghai hongqu biomedical technology co. LTD Gold
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Changzhou Chenhong Biotechnology Co., Ltd. Gold
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0519-85788828 13775037613
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