STF-62247 Chemical Properties

Melting point:

158-160℃

Density 

1.255

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO: soluble26mg/mL

form 

solid

color 

Off-white

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26-39

WGK Germany 

2

STF-62247 Usage And Synthesis

Description

STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable

Uses

Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity.

Definition

ChEBI: N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline.

in vitro

in vitro study demonstrated that stf-62247 exhibited selectively cytotoxicity and tumor growth inhibitory activity towards wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively. in addion, stf-62247 also resulted in cell apoptosis by inducing acidification and increasing autophagy in vhl-deficient cells. [1]

in vivo

animal experiments for stf-62247 activity were performed according to institutional and national guidelines and approved by stanford university's administrative panel on laboratory animal care. based on an in vivo mouse model, it was found that intraperitoneal injection of stf-62247 at a dose of 8 mg/kg significantly inhibited tumor growth of vhl-deficient sn12c tumor cells. [1]

IC 50

stf-62247 inhibits tumor growth in wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively.

References

1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944 2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987 3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388

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