H2N-PEG2-Propyne Chemical Properties

Boiling point:

213.8±20.0 °C(Predicted)

Density 

0.992±0.06 g/cm3(Predicted)

refractive index 

1.4590 to 1.4630

Flash point:

88°

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO:100.0(Max Conc. mg/mL);698.37(Max Conc. mM)

form 

clear liquid

pka

8.72±0.10(Predicted)

color 

Colorless to Almost colorless

Appearance

colorless to yellow liquid

Safety Information

RIDADR 

UN 2735 8/PG II

HS Code 

2922.19.9690

HazardClass 

8

PackingGroup 

II

H2N-PEG2-Propyne Usage And Synthesis

Description

Propargyl-PEG2-amine is a crosslinker that is reactive with NHS esters, carbonyls (carboxylic acid, ketone, aldehyde). The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reaction to form a stable triazole linkage.

Uses

2-[2-(2-Propynyloxy)ethoxy]ethylamine is used in preparation of RSV F protein inhibitors conjugated to Fc variants and albumins.

Synthesis

The general procedure for the synthesis of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethylamine from the compound (CAS:1245006-63-6) is as follows: General method: polymer-loaded triphenylphosphine (1.15 eq.) was added to an anhydrous tetrahydrofuran (THF) solution of azide alkynes S3. Subsequently, the reaction mixture was stirred at room temperature for 48 hours. Next, deionized water (1 mL) was added to the flask and the resulting mixture was continued to be stirred at room temperature for 48 hours. Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth to collect insoluble solids and washed with ethyl acetate (25 mL). Finally, the combined filtrates were concentrated under reduced pressure to give the target product aminoalkynes 6.

IC 50

Non-cleavable Linker; PEGs

References

[1] Molecules, 2013, vol. 18, # 9, p. 11639 - 11657
[2] Journal of the American Chemical Society, 2010, vol. 132, # 36, p. 12711 - 12716
[3] Drug Design, Development and Therapy, 2018, vol. 12, p. 987 - 995
[4] Journal of Porphyrins and Phthalocyanines, 2013, vol. 17, # 1-2, p. 104 - 117

H2N-PEG2-Propyne(944561-44-8)Related Product Information

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