2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Chemical Properties

Melting point:

206-209℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)

form 

Solid

color 

White to Off-White

Water Solubility 

Slightly soluble in water.

Stability:

Hygroscopic

Safety Information

HS Code 

2933399990

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Usage And Synthesis

Chemical Properties

white to yellow Solid.

Uses

It is employed as a intermediate for pharmaceutical.

Uses

2,6-Diazaspiro[3.3]heptane-2-carboxylic Acid tert-Butyl Ester Hemioxylate is preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.

Preparation

Synthesis of 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate: Take a 500mL single-necked bottle, add 6-toluenesulfonyl-2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester (7g, 20mmol), dissolve in methanol (200mL), add magnesium chips (3.84 g) g, 0.16 mol, 8 equiv) and stirred at room temperature. The reaction solution gradually turned into a white viscous state with the dissolution of the magnesium scraps, and TLC showed that the reaction of the raw materials was completed. The solvent was removed by rotary evaporation, ether (150 mL) was added, stirred at room temperature for 1 h, filtered through celite, the filtrate was dried over anhydrous sodium sulfate, and an ethanol solution (3 mL) of anhydrous oxalic acid (0.89 g, 9.9 mmol, 0.5 equiv) was added dropwise, A white precipitate appeared immediately, which was filtered under reduced pressure to give 3.2 g of a colorless solid, 82%.

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate(1041026-71-4)Related Product Information

• tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
• tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate hydrochloride
• tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
• 2,3,3a,8a-Tetrahydro-1H-2-aza-cyclopenta[a]inden-8-one
• 1-Oxa-4,8-diazaspiro[5.5]undecan-8-carboxylic acid tert-butyl ester
• 3-Azabicyclo[3.1.0]hexane-3,6-dicarboxylic acid 3-tert-butyl ester
• 7-Boc-1,7-diaza-spiro[4.4]nonane
• Tert-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate
• 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE
• 2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID
• Carbamic acid, 3-azabicyclo[3.1.0]hex-1-yl-, 1,1-dimethylethyl ester (9CI)
• 4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE
• BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
• Tert-butyl 1,7-diazaspiro[4,4]nonane-1-carboxylate
• Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate
• benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
• 2S-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester