7-Chloro-1,2,3,4-tetrahydroquinoline Chemical Properties

Boiling point:

273.0±29.0 °C(Predicted)

Density 

1.162±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

4.26±0.20(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933491090

7-Chloro-1,2,3,4-tetrahydroquinoline Usage And Synthesis

Synthesis

General procedure for the synthesis of 7-chloro-1,2,3,4-tetrahydroquinoline from 7-chloroquinoline: In a 10 mL Schlenk tube, Fe(OTf)2 (0.005 mmol, 1.8 mg), 7-chloroquinoline (0.5 mmol, 72 mg), Hantzsch ester A (1.25 mmol, 318 mg) and 1.0 mL of CHCl3. The reaction mixture was stirred at 40 °C for 2 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to afford pure 7-chloro-1,2,3,4-tetrahydroquinoline (63.8 mg, 96% yield).

References

[1] Journal of the American Chemical Society, 2018, vol. 140, # 12, p. 4417 - 4429
[2] Tetrahedron Letters, 2017, vol. 58, # 36, p. 3571 - 3573
[3] Patent: US2003/229026, 2003, A1. Location in patent: Page 25

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