2,3-Dichlorobenzaldehyde Chemical Properties

Melting point:

64-67 °C (lit.)

Boiling point:

143-145°C 30mm

Density 

1.33

refractive index 

1.5756 (estimate)

Flash point:

135°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Practically insoluble in water

form 

Crystalline Powder

color 

White

PH

4.17 at 23.5℃ and 10g/L

Sensitive 

Air Sensitive

BRN 

508198

LogP

2.6 at 30℃ and pH7.96

CAS DataBase Reference

6334-18-5(CAS DataBase Reference)

EPA Substance Registry System

Benzaldehyde, 2,3-dichloro- (6334-18-5)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-37/39

RIDADR 

UN 3261 8/PG 2

WGK Germany 

2

F 

10

Hazard Note 

Corrosive

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29130000

MSDS

• Language:English Provider:2,3-Dichlorobenzaldehyde
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2,3-Dichlorobenzaldehyde Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

2,3-Dichlorobenzaldehyde has been used in preparation of:

• 4-(2,3-dichlorobenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, Schiff base
• ethyl 4-(2,3-dichlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate via Biginelli condensation
• benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Synthesis

(1) Device construction: Configure the tubular reactor system with reference to Figure 2, using a (3a + 3e) type DC channel combined with tubing of Corning Heart Cel 1 construction. Select the appropriate pipe diameter and reactor volume according to the reactant flow rate and required reaction time. Heat transfer oil was selected as the heat transfer medium. (2) Solution preparation: The catalyst solution was prepared by dissolving 6.06 g of cobalt acetate and 6.06 g of sodium molybdate in 200 mL of a mixed solvent of 2,3-dichlorotoluene and 200 mL of acetic acid, where the molar ratio of cobalt acetate to 2,3-dichlorotoluene was 0.015:1. The hydrogen peroxide-acetic acid solution was also prepared by dissolving 6.06 g of sodium bromide in a 25% aqueous hydrogen peroxide solution. The molar ratio of sodium bromide to 2,3-dichlorotoluene was 0.015:1. (3) Reaction process: When the molar ratio of hydrogen peroxide to 2,3-dichlorotoluene was 2:1, 2,3-dichlorotoluene-acetic acid solution and hydrogen peroxide-acetic acid solution were pumped into a preheated microchannel reactor (shown in Fig. 2) at flow rates of 5.56 mL/min and 111 mL/min, respectively. The reaction temperature was controlled to be 90 °C and the residence time was 1200 s. After the reaction was completed, the outlet material was cooled to 0 °C and the reaction was quenched with methylene chloride. The conversion of 2,3-dichlorotoluene was 42.8% and the yield of 2,3-dichlorobenzaldehyde was 29.0% as analyzed by gas chromatography.

References

[1] Patent: CN106699525, 2017, A. Location in patent: Paragraph 0039; 0040
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 861,863
[3] Industrial and Engineering Chemistry, 1947, vol. 39, p. 1486,1487
[4] Journal of the Chemical Society. Perkin transactions 1, 1965, p. 5976 - 5983
[5] Patent: CN107032968, 2017, A

2,3-Dichlorobenzaldehyde(6334-18-5)Related Product Information

• Benzaldehyde
• p-Anisaldehyde
• 2-Nitrobenzaldehyde
• 3-Methoxybenzaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 4-Hydroxybenzaldehyde
• Salicylaldehyde
• 4-Dimethylaminobenzaldehyde
• 2,3,5-Trichlorobenzaldehyde
• 3,4,5,6-TETRACHLOROFLUORESCEIN
• Tetrachlorophthalic anhydride
• 3,5-Dichlorobenzaldehyde
• 2,3-Dichlorobenzoic acid
• 2,3-Dichlorobenzoyl chloride
• 2,5-Dichlorobenzaldehyde
• 2,6-Dichlorobenzaldehyde
• 2,3,6-TRICHLOROBENZALDEHYDE
• 2,4-Dichlorobenzaldehyde