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3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE

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3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE Basic information

Product Name:
3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE
Synonyms:
  • RARECHEM AL BW 1078
  • 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE
  • 3-[3-(Trifluoromethyl)phenyl]-1-propanamine
  • 3-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-1-AMINE
  • 3-(TrifluoroMethyl)-benzenepropanaMine
  • Cinacalcet metabolite M4
  • Cicalcet metabolite M4
  • Cinacalcet 3-TFM Amine Impurity
CAS:
104774-87-0
MF:
C10H12F3N
MW:
203.2
Mol File:
104774-87-0.mol
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3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE Chemical Properties

Boiling point:
222.2±40.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Oil
pka
10.20±0.10(Predicted)
color 
Colourless
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3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE Usage And Synthesis

Uses

Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease[1][2].

References

[1] Kumar GN, et al. Metabolism and disposition of calcimimetic agent cinacalcet HCl in humans and animalmodels. Drug Metab Dispos. 2004 Dec;32(12):1491-500. DOI:10.1124/dmd.104.000604
[2] Bushinsky DA, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. DOI:10.1038/sj.ki.5000324

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