5-Hydroxypentanoic Acid SodiuM Salt Chemical Properties

Melting point:

162-164°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

HS Code 

2918199890

5-Hydroxypentanoic Acid SodiuM Salt Usage And Synthesis

Synthesis

General procedure for the synthesis of sodium 5-hydroxyvalerate from tetrahydro-2H-pyran-2-one: Tetrahydro-2H-pyran-2-one (1.0 g, 10 mmol) was added to a 90% ethanol solution (23 mL) containing NaOH (0.44 g, 11 mmol). The reaction mixture was stirred at 80°C for 30 minutes, followed by continued stirring at room temperature for 2 hours. Upon completion of the reaction, the excess solvent was removed by distillation under reduced pressure to quantitatively obtain sodium 5-hydroxyvalerate.

References

[1] ChemMedChem, 2017, vol. 12, # 3, p. 226 - 234
[2] Tetrahedron, 2017, vol. 73, # 14, p. 1873 - 1880
[3] Journal of the American Chemical Society, 2004, vol. 126, # 42, p. 13588 - 13589
[4] Journal of Organic Chemistry, 2014, vol. 79, # 10, p. 4358 - 4366
[5] Journal of the American Chemical Society, 1929, vol. 51, p. 261

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