WP1066
WP1066 Basic information
- Product Name:
- WP1066
- Synonyms:
-
- WP1066
- (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
- WP1066/WP-1066
- (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066
- WP1066, >=99%
- wp1066(STAT Inhibitor III)
- Stat3 Inhibitor III, WP1066
- CAS:
- 857064-38-1
- MF:
- C17H14BrN3O
- MW:
- 356.22
- Product Categories:
-
- Inhibitors
- JAK
- Inhibitor
- STAT
- API
- Mol File:
- 857064-38-1.mol
WP1066 Chemical Properties
- Melting point:
- 90-93oC
- Boiling point:
- 569.9±50.0 °C(Predicted)
- Density
- 1.425
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- form
- Off-white solid
- pka
- 11.00±0.46(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
WP1066 Usage And Synthesis
Description
WP1066 is a cell-
Uses
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.
target
JAK2
References
1) Kong?et al.?(2005),?Discovery of WP1066, a novel Stat3/c-myc inhibitor with potent antitumor activity against human melanoma in vitro and in vivo;?Cancer Res.?65?1387 2) Iwamaru?et al.?(2007),?A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both invitro and in vivo;?Oncogene?26?2435 3) Ferraioli?et al.?(2007),?WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in acute Myelogenous Leukemia Cells;?Cancer Res.?67?11291 4) Kong,?et al.?(2008),?A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells;?Clin. Cancer Res.?14?5759 5) Kong,?et al.?(2009),?A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells;?Cancer Immunol. Immunother.?58?1023 6) Ma,?et al.?(2017),?Stat3 inhibitor abrogates the expression of PD-1 ligands on Lymphoma cell lines;?J. Clin. Exp. Hematop.?57?21
WP1066Supplier
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- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
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- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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- 021-58950125
- info@chemexpress.com
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- 400-400-6206333 18521732826
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