3,6-DibroMo-4-Methyl-pyridazine Chemical Properties

Melting point:

103.5 °C

Boiling point:

337.8±37.0 °C(Predicted)

Density 

2.022±0.06 g/cm3(Predicted)

storage temp. 

-20°C, sealed storage, away from moisture

pka

-0.56±0.10(Predicted)

Appearance

Pale purple to purple Solid

InChI

InChI=1S/C5H4Br2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3

InChIKey

RQBKJQQWXNALHH-UHFFFAOYSA-N

SMILES

C1(Br)=NN=C(Br)C=C1C

Safety Information

HS Code 

2933998090

3,6-DibroMo-4-Methyl-pyridazine Usage And Synthesis

Synthesis

General procedure for the synthesis of 3,6-dibromo-4-methylpyridazine from 3,6-dichloro-4-methylpyridazine: 3,6-dichloro-4-methylpyridazine (10 g, 61.3 mmol) was suspended in a 30-33% hydrobromic acid solution in acetic acid (200 mL), and the reaction was allowed to stand for 24 hours at room temperature. Upon completion of the reaction, the precipitate was collected by filtration. The resulting precipitate was resuspended in dichloromethane and neutralized with saturated aqueous sodium bicarbonate. The organic layer was separated, washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give 3,6-dibromo-4-methylpyridazine (6.8 g, 44% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.50 (d, J = 1.2 Hz, 1H), 2.41 (d, J = 0.6 Hz, 3H); LC-MS showed a molecular ion peak of 253.1 [M + 3H].

References

[1] Patent: WO2016/185342, 2016, A1. Location in patent: Page/Page column 44

3,6-DibroMo-4-Methyl-pyridazine(89284-10-6)Related Product Information

• 4-Bromo-3,6-dichloropyridazine
• 3,6-dichloropyridazin-4-amine