ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Endocrinology & Hormones > GPR antagonist > OC000459
OC000459
OC000459 Basic information
- Product Name:
- OC000459
- Synonyms:
-
- OC000459
- 2-(5-fluoro-2-Methyl-3-(quinolin- 2-ylMethyl)-1H-indol-1-yl)acetic acid
- 5-Fluoro-2-Methyl-3-quinolin-2-ylMethylindo-1-yl)-acetic(OC000459)
- [5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid
- 5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid
- OC000495
- (5-Fluoro-3-isoquinolin-3-ylMethyl-2-Methyl-indol-1-yl)-acetic acid
- 1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
- CAS:
- 851723-84-7
- MF:
- C21H17FN2O2
- MW:
- 348.37
- Product Categories:
-
- Inhibitors
- Mol File:
- 851723-84-7.mol
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OC000459 Chemical Properties
- Boiling point:
- 574.4±50.0 °C(Predicted)
- Density
- 1.29
- storage temp.
- Store at -20°C
- solubility
- DMF: 0.5 mg/ml; DMSO: 1.1 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 4.08±0.10(Predicted)
- color
- Light yellow to yellow
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OC000459 Usage And Synthesis
Uses
OC000459 is a CRTH2 antagonist which helps in the treatment of allergies, reducing nasal and ocular symptoms in subjects exposed to allergens.
in vivo
Timapiprant (OC000459) (gavage; 2 mg/kg, 10 mg/kg) inhibits blood eosinophilia induced by 13,14-dihydro-15-keto-PGD2 (DK-PGD2) in Rat (ED50=0.04 mg/kg)[1]. Timapiprant (OC000459) (gavage; 0.01 mg/kg, 0.1 mg/kg, 1.0 mg/kg) inhibits airway eosinophilia in response to an aerosol of DK-PGD2 in guinea pigs (ED50=0.01 mg/kg)[1].
IC 50
DP
OC000459Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
NCE Biomedical Co.,Ltd.
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988