Amorolfine hydrochloride
Amorolfine hydrochloride Basic information
- Product Name:
- Amorolfine hydrochloride
- Synonyms:
-
- AMOROLFINE HCL
- Amorolfine HCI
- Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel-
- Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-
- Ro 14-4767/002
- (+/-)-cis-2,6-Dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine hydrochloride
- Amorolfine hydrochloride
- (2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, hydrochloride (1:1)
- CAS:
- 78613-38-4
- MF:
- C21H36ClNO
- MW:
- 353.98
- EINECS:
- 689-236-9
- Product Categories:
-
- HYTRIN
- Antifungal (Topical)
- Antifungals for Research and Experimental Use
- Biochemistry
- 78613-38-4
- Mol File:
- 78613-38-4.mol
Amorolfine hydrochloride Chemical Properties
- Boiling point:
- 120 C
- storage temp.
- room temp
- solubility
- DMSO: ≥5mg/mL (warmed)
- form
- powder
- color
- white to beige
- InChIKey
- XZKWIPVTHGWDCF-KUZYQSSXSA-N
- CAS DataBase Reference
- 78613-38-4(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,N
- Risk Statements
- 20/21/22-36/37/38-50/53-38-22
- Safety Statements
- 26-36-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HS Code
- 29411010
Amorolfine hydrochloride Usage And Synthesis
Description
Amorolfine hydrochloride is the first morpholine antifungal agent useful in the topical treatment of onychomycosis. Mechanistically, it appears to inhibit two stages of the ergosterol biosynthetic pathway, which is necessary for fungal cell viability. Active against a broad spectrum of fungi, amorolfiie hydrochloride is particularly effective against yeasts such as Histoplasma capsulatum, dermatophytes and dematiaceous fungi.
Chemical Properties
Liquid
Originator
Roche (Switzerland)
Uses
Amorolfine hydrochloride has been used as an antifungal agent.
Uses
antihypertensive
Definition
ChEBI: A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal ag nt, it is used for the topical treatment of fungal nail and skin infections.
brand name
Loceryl (Hoffmann-LaRoche).
Biochem/physiol Actions
Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.
Amorolfine hydrochlorideSupplier
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Amorolfine hydrochloride(78613-38-4)Related Product Information
- Moroxydine hydrochloride
- Moroxydine
- Amorolfine hydrochloride
- 1-AdaMantanethylaMine
- ISOPROPYLHYDRAZINE HYDROCHLORIDE
- Amorolfine
- Topotecan hydrochloride
- Tridemorph
- Dimethomorph
- Hydroxylamine hydrochloride
- Tramadol hydrochloride
- cis-2,6-Dimethylmorpholine
- Dimethylmorpholine
- Sibutramine hydrochloride
- N-[2-(acetyloxy)propyl]-N-[3-[4-(1,1-diMethylpropyl)phenyl]-2-Methylpropyl]-forMaMide
- Amorolfine Impurity 6
- Amorolfine Impurity 11
- 4-[3-[4-(1,1-diMethylpropyl)-phenyl]-2-Methylpropyl]-2,6-diMethylMorpholine 4-oxide