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Amorolfine hydrochloride

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Amorolfine hydrochloride Basic information

Product Name:
Amorolfine hydrochloride
Synonyms:
  • AMOROLFINE HCL
  • Amorolfine HCI
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel-
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-
  • Ro 14-4767/002
  • (+/-)-cis-2,6-Dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine hydrochloride
  • Amorolfine hydrochloride
  • (2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, hydrochloride (1:1)
CAS:
78613-38-4
MF:
C21H36ClNO
MW:
353.98
EINECS:
689-236-9
Product Categories:
  • HYTRIN
  • Antifungal (Topical)
  • Antifungals for Research and Experimental Use
  • Biochemistry
Mol File:
78613-38-4.mol
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Amorolfine hydrochloride Chemical Properties

Boiling point:
120 C
storage temp. 
room temp
solubility 
DMSO: ≥5mg/mL (warmed)
form 
powder
color 
white to beige
InChIKey
XZKWIPVTHGWDCF-KUZYQSSXSA-N
CAS DataBase Reference
78613-38-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
20/21/22-36/37/38-50/53-38-22
Safety Statements 
26-36-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
29411010
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Amorolfine hydrochloride Usage And Synthesis

Description

Amorolfine hydrochloride is the first morpholine antifungal agent useful in the topical treatment of onychomycosis. Mechanistically, it appears to inhibit two stages of the ergosterol biosynthetic pathway, which is necessary for fungal cell viability. Active against a broad spectrum of fungi, amorolfiie hydrochloride is particularly effective against yeasts such as Histoplasma capsulatum, dermatophytes and dematiaceous fungi.

Chemical Properties

Liquid

Originator

Roche (Switzerland)

Uses

antihypertensive

Definition

ChEBI: A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal ag nt, it is used for the topical treatment of fungal nail and skin infections.

brand name

Loceryl (Hoffmann-LaRoche).

Amorolfine hydrochlorideSupplier

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