BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Chemical Properties

Boiling point:

601.1±65.0 °C(Predicted)

Density 

1.50±0.1 g/cm3(Predicted)

solubility 

DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml

pka

8.76±0.20(Predicted)

form 

Powder

color 

White to off-white

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Usage And Synthesis

Description

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC₅₀ = 0.5 μM). It increases Wnt signaling in U2OS osteosarcoma cells (EC₅₀ = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.

Definition

ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound.

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