PSI 7851 Chemical Properties

Density 

1.41±0.1 g/cm3(Predicted)

pka

9.39±0.10(Predicted)

PSI 7851 Usage And Synthesis

Uses

GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1].

References

[1] Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection
[2] Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus J. Med. Chem., Article ASAP DOI: 10.1021/jm100863x Publication Date (Web): September 16, 2010

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