Basic information Safety Supplier Related

XL-647

Basic information Safety Supplier Related

XL-647 Basic information

Product Name:
XL-647
Synonyms:
  • Tesevatinib
  • Tesevatinib(XL647)
  • XL-647
  • N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine
  • N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine
  • EXEL-7647;XL-647;XL 647
  • KD-019
  • Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
CAS:
781613-23-8
MF:
C24H25Cl2FN4O2
MW:
491.3853032
Mol File:
781613-23-8.mol
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XL-647 Chemical Properties

Boiling point:
567.9±50.0 °C(Predicted)
Density 
1.356
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form 
A solid
pka
10.16±0.40(Predicted)
color 
White to off-white
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XL-647 Usage And Synthesis

Uses

XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.

Definition

ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.

XL-647Supplier

Jiangsu yize medical technology co. LTD Gold
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Jiangsu yize medical technology co. LTD Gold
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18962082606
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3394205705@qq.com
Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
Chembest Research Laboratories Limited
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Haoyuan Chemexpress Co., Ltd.
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