XL-647
XL-647 Basic information
- Product Name:
- XL-647
- Synonyms:
-
- Tesevatinib
- Tesevatinib(XL647)
- XL-647
- N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine
- N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine
- EXEL-7647;XL-647;XL 647
- KD-019
- Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
- CAS:
- 781613-23-8
- MF:
- C24H25Cl2FN4O2
- MW:
- 491.3853032
- Mol File:
- 781613-23-8.mol
XL-647 Chemical Properties
- Boiling point:
- 567.9±50.0 °C(Predicted)
- Density
- 1.356
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
- form
- A solid
- pka
- 10.16±0.40(Predicted)
- color
- White to off-white
XL-647 Usage And Synthesis
Uses
XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.
Definition
ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.
XL-647Supplier
- Tel
- 18962082606
- 3394205705@qq.com
- Tel
- 18962082606
- 3394205705@qq.com
- Tel
- sales@boylechem.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-58950125
- info@chemexpress.com
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