Octaethylene glycol di(p-toluenesulfonate)
Octaethylene glycol di(p-toluenesulfonate) Basic information
- Product Name:
- Octaethylene glycol di(p-toluenesulfonate)
- Synonyms:
-
- Octaethylene glycol di(p-toluenesulfonate)
- Tos-PEG9-Tos
- 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol,bis(4-methylbenzenesulfonate)
- 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate)
- 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, 1,23-bis(4-methylbenzenesulfonate)
- Tos-PEG8-Tos/3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, 1,23-bis(4-methylbenzenesulfonate)
- 23-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12,15,18,21-heptaoxatricosan-1-yl 4-methylbenzene-1-sulfonate
- TSO-PEG8-OTS
- CAS:
- 57436-38-1
- MF:
- C30H46O13S2
- MW:
- 678.81
- Mol File:
- 57436-38-1.mol
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Octaethylene glycol di(p-toluenesulfonate) Usage And Synthesis
Description
Tos-PEG9-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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