Basic information Safety Supplier Related

Boc-NH-PEG(5)-COOH(22atoMs)

Basic information Safety Supplier Related

Boc-NH-PEG(5)-COOH(22atoMs) Basic information

Product Name:
Boc-NH-PEG(5)-COOH(22atoMs)
Synonyms:
  • Boc-NH-PEG(5)-COOH(22atoMs)
  • Boc-NH-PEG(5)-COOH
  • Boc-NM-PEG6-CM2COOH
  • 2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid
  • t-Boc-N-amido-PEG6-CH2CO2H
  • t-boc-N-amido-PEG6-acetic acid
  • NHBoc-PEG6-CH2COOH
  • Inhibitor,Boc-NH-PEG-6-CH2COOH,PROTAC Linkers,BocNHPEG6CH2COOH,Boc NH PEG6 CH2COOH,inhibit
CAS:
391684-36-9
MF:
C19H37NO10
MW:
439.5
Mol File:
391684-36-9.mol
More
Less

Boc-NH-PEG(5)-COOH(22atoMs) Chemical Properties

Boiling point:
557.7±50.0 °C(Predicted)
Density 
1.134±0.06 g/cm3(Predicted)
storage temp. 
-20°C
pka
3.39±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
More
Less

Boc-NH-PEG(5)-COOH(22atoMs) Usage And Synthesis

Description

t-Boc-N-amido-PEG6-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Boc-NH-PEG(5)-COOH(22atoMs)Supplier

Shanghai Huici Pharmaceutical Technology Co., LTD Gold
Tel
19372841038 19372841038
Email
lixing@pharmahuici.com
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Email
sales@pharmablock.com
T&W GROUP
Tel
021-61551611 13296011611
Email
contact@trustwe.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Email
info@amateksci.com