PluriSln 1 Chemical Properties

Melting point:

177-178℃

Boiling point:

335.7±15.0 °C(Predicted)

Density 

1.251±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO: soluble15mg/mL, clear

pka

10.69±0.23(Predicted)

form 

powder

color 

white to beige

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

HS Code 

2933.39.9200

PluriSln 1 Usage And Synthesis

Description

PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3.

Uses

NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

storage

+4°C

References

[1] URI BEN-DAVID. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.[J]. Cell stem cell, 2013, 12 2: 167-179. DOI:10.1016/j.stem.2012.11.015
[2] LAN ZHANG. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium.[J]. Cell Cycle, 2014, 13 5: 762-771. DOI:10.4161/cc.27677
[3] AIXIN CHENG. Cartilage repair using human embryonic stem cell-derived chondroprogenitors.[J]. Stem Cells Translational Medicine, 2014, 3 11: 1287-1294. DOI:10.5966/sctm.2014-0101

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