3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Chemical Properties

Boiling point:

353.7±32.0 °C(Predicted)

Density 

1.182±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

form 

powder

pka

13.38±0.46(Predicted)

color 

white to beige

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26-24/25

RIDADR 

3077

WGK Germany 

3

HS Code 

29242990

3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Usage And Synthesis

Description

NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3

Uses

NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.

storage

Store at RT

References

1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339 2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167 3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945

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