Basic information Safety Supplier Related

PF 4618433

Basic information Safety Supplier Related

PF 4618433 Basic information

Product Name:
PF 4618433
Synonyms:
  • PF 4618433
  • 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(pyridin-3-yloxymethyl)-1H-pyrazol-3-yl]urea
  • PF-4618433 >=95%
  • PF 4618433; PF4618433
  • CS-2665
  • Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[3-[(3-pyridinyloxy)methyl]-1H-pyrazol-5-yl]-
  • PF4618433 @3
  • PF4618433 @2,PF4618433 @3
CAS:
1166393-85-6
MF:
C24H27N7O2
MW:
445.52
Mol File:
1166393-85-6.mol
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PF 4618433 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (280.57 mM)
form 
Solid
color 
White to off-white
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PF 4618433 Usage And Synthesis

Uses

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2].

References

[1] Seungil H, et, al. Structural Characterization of Proline-Rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design. J Biol Chem. 2009 May 8; 284(19): 13193-201. DOI:10.1074/jbc.M809038200
[2] Sumana P, et, al. A Pyk2 Inhibitor Incorporated Into a PEGDA-gelatin Hydrogel Promotes Osteoblast Activity and Mineral Deposition. Biomed Mater. 2019 Feb 27; 14(2): 025015. DOI:10.1088/1748-605X/aafffa

PF 4618433Supplier

AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Email
info@adooq.cn
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Email
sales@pharmacodia.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
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PF 4618433(1166393-85-6)Related Product Information