(R)-3-PHENYLBUTYRIC ACID Chemical Properties

Boiling point:

94-95 °C/0.3 mmHg (lit.)

Density 

1.069 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.517

pka

4.67±0.10(Predicted)

optical activity

[α]20/D 57±2°, c = 1% in benzene

BRN 

2501477

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

MSDS

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(R)-3-PHENYLBUTYRIC ACID Usage And Synthesis

Chemical Properties

optical purity >99%

Purification Methods

Purify the acids as the 2-isomer above, i.e. by distillation, but under a good vacuum. [Prelog & Scherrer Helv Chim Acta 42 2227 1959, Levene & Marker J Biol Chem 93 761 1932, 100 685 1933, Cram J Am Chem Soc 74 2137 1952.] The R-amide crystallises from H2O, with m 101.5-102o, and [] 20 -16.5o (c 1.2, EtOH). The racemic acid has m 39-40o, b 134-136o/6mm, 158o/12mm [Marvel et al. J Am Chem Soc 62 3499 1940]. [Beilstein 9 IV 1813.]

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