Basic information Safety Supplier Related

AICAR (phosphate)

Basic information Safety Supplier Related

AICAR (phosphate) Basic information

Product Name:
AICAR (phosphate)
Synonyms:
  • AICAR (Acadesine) phosphate
  • AICAR (phosphate)
  • 5-Amino-1-ribosylimidazole-4-carboxamide phosphate
  • AICAR phosphate, >98%
  • AICA Riboside phosphate)
  • AICAR phosphate (Acadesine phosphate
  • Acadesine phosphate
  • ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE
CAS:
681006-28-0
MF:
C9H17N4O9P
MW:
356.23
Mol File:
681006-28-0.mol
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AICAR (phosphate) Chemical Properties

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
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AICAR (phosphate) Usage And Synthesis

Biological Activity

aicar phosphate (acadesine)is an activator of ampk [1].aicar phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the ec50 value is 380±60μm on the viability assay of b-cll cells. in addition, aicar phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in b-cll cells. furthermore, aicar phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate ampk. apart from these, aicar phosphate (2-4 mm) has shown to only slightly affects the viability of t cells from b-cll patients, aicar phosphate (0.5 mm) has been noted to remarkedly reduces viability of b cells but not t cells [1].

References

[1] campàs c1, lopez jm, santidrián af, barragán m, bellosillo b, colomer d, gil j. acadesine activates ampk and induces apoptosis in b-cell chronic lymphocytic leukemia cells but not in t lymphocytes. blood. 2003 may 1;101(9):3674-80. epub 2003 jan 9.

AICAR (phosphate)Supplier

Haoyuan Chemexpress Co., Ltd.
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021-58950125
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info@chemexpress.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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3003855609@qq.com
LETOPHARM LIMITED
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+86-21-5821 5861
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sales@letopharm.com
SPIRO PHARMA
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Email
eric_feng1954@126.com
Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 4009686088
Email
3193328036@qq.com
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AICAR (phosphate)(681006-28-0)Related Product Information