3-(Benzylamino)propylamine Chemical Properties

Boiling point:

102°C/1mmHg(lit.)

Density 

0.979±0.06 g/cm3(Predicted)

refractive index 

1.5320

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Liquid

pka

9.97±0.10(Predicted)

color 

Pale yellow

Safety Information

Hazard Codes 

Xi

RIDADR 

UN 2735 8/PG III

HazardClass 

8

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

2921599090

3-(Benzylamino)propylamine Usage And Synthesis

Synthesis

GENERAL METHOD: A mixture of benzaldehyde and ethylenediamine (molar ratio 5:1) in toluene was refluxed in a Dean-Stark apparatus for 5 hours. After completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in ethanol. NaBH4 (molar ratio 1:2.5) was slowly added at 0°C, followed by continued stirring for 4 hours at room temperature. At the end of the reaction, ethanol was removed under reduced pressure and the residue was dissolved in dichloromethane and washed with saturated saline. The organic phase was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting residue was purified by fast column chromatography using a mixture of dichloromethane/methanol/33% ammonia (9:1:0.1, v/v) as eluent, and the target product 3-benzylaminopropylamine was finally obtained.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 57, p. 417 - 428

3-(Benzylamino)propylamine(13910-48-0)Related Product Information

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