tert-Butyl 1-piperazinecarboxylate Chemical Properties

Melting point:

43-47 °C(lit.)

Boiling point:

98-100

Density 

1.030±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Soluble in DMSO

pka

8.45±0.10(Predicted)

form 

Low Melting Crystalline Mass

color 

White to light yellow

Water Solubility 

Soluble in ethyl acetate, methanol and water.

Sensitive 

Air Sensitive

BRN 

879985

InChIKey

CWXPZXBSDSIRCS-UHFFFAOYSA-N

CAS DataBase Reference

57260-71-6(CAS DataBase Reference)

NIST Chemistry Reference

T-butyl 1-piperaziencarboxylate(57260-71-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3263

WGK Germany 

3

F 

3-10-34

HazardClass 

IRRITANT

HS Code 

29335995

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

tert-Butyl 1-piperazinecarboxylate Usage And Synthesis

Uses

N-Boc-piperazine is a compound useful in organic synthesis.

Chemical Properties

Waxy Solid

Uses

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

Uses

1-Boc-piperazine may be used in:

• preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
• termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
• preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors

Application

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.

General Description

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K₃PO₄ (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

tert-Butyl 1-piperazinecarboxylate(57260-71-6)Related Product Information

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