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ME0328

Basic information Safety Supplier Related

ME0328 Basic information

Product Name:
ME0328
Synonyms:
  • ME0328; ME 0328; ME-0328
  • 4-Dihydro-4-oxo-3
  • 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
  • ME0328
  • 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
  • (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
  • 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-
  • ME0328 USP/EP/BP
CAS:
1445251-22-8
MF:
C19H19N3O2
MW:
321.37
EINECS:
808-923-8
Product Categories:
  • Inhibitors
Mol File:
1445251-22-8.mol
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ME0328 Chemical Properties

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-43
Safety Statements 
36/37
WGK Germany 
3
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ME0328 Usage And Synthesis

Description

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

Uses

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

References

1) Lindgren?et al. (2013),?PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ART3/PARP3; ACS Chem. Biol.,8?1689

ME0328Supplier

Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
zhangsn@titansci.com
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Email
marketing@targetmol.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Target molecule Corp.
Tel
857-239-0968
Email
service1@targetmol.com