ME0328 Chemical Properties

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO: soluble10mg/mL, clear

form 

powder

color 

white to beige

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-43

Safety Statements 

36/37

WGK Germany 

3

ME0328 Usage And Synthesis

Description

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC₅₀ = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

Uses

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

IC 50

ARTD3/PARP3: 0.89 μM (IC₅₀); ARTD1/PARP1: 6.3 μM (IC₅₀); ARTD2/PARP2: 10.8 μM (IC₅₀); ARTD6/TNKS2: 34.3 μM (IC₅₀); ARTD5/TNKS1: 47.3 μM (IC₅₀); ARTD10/PARP10: 71.3 μM (IC₅₀)

References

[1] ANDERS E. G. LINDGREN. PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3[J]. ACS Chemical Biology, 2013, 8 8: 1698-1703. DOI:10.1021/cb4002014

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