Basic information Safety Supplier Related

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea

Basic information Safety Supplier Related

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Basic information

Product Name:
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea
Synonyms:
  • Sorafenib related coMpound 4
  • 1-(4-chloro-3-(trifluromethyl)phenyl)-3-(4-hydroxyphenyl)urea
  • Sorafenib impurity 17/1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea
  • Sorafenib Impurity 65
  • Sorafenib impurities166
  • Sorafenib impurities5
  • Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)-
CAS:
1129683-83-5
MF:
C14H10ClF3N2O2
MW:
330.69
Mol File:
1129683-83-5.mol
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N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Chemical Properties

Boiling point:
350.1±42.0 °C(Predicted)
Density 
1.547±0.06 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.16±0.26(Predicted)
color 
White to Light Yellow
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N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Usage And Synthesis

Uses

1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea is an impurity of Sorafenib (S676850), a kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis.

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