Thiazolidine-4-carboxylic acid Chemical Properties

Melting point:

196.5°C

Boiling point:

350.3±37.0 °C(Predicted)

Density 

1.226 (estimate)

refractive index 

1.5480 (estimate)

storage temp. 

Room Temperature

solubility 

DMSO (Slightly), Water (Slightly)

form 

solid

pka

2.09±0.20(Predicted)

color 

White to off-white

Water Solubility 

29.3g/L(21 ºC)

CAS DataBase Reference

444-27-9(CAS DataBase Reference)

EPA Substance Registry System

4-Thiazolidinecarboxylic acid (444-27-9)

Safety Information

RIDADR 

2811

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:1,3-Thiazolidine-4-carboxylic acid

Thiazolidine-4-carboxylic acid Usage And Synthesis

Originator

Hepaldine,Riker,France,1964

Uses

hepatoprotectant

Uses

Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells.

Definition

ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.

Manufacturing Process

Cysteine is first dissolved in distilled water which has been freed of oxygen by boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and the temperature of the mixture rises, while the thiazolidine carboxylic acid begins crystallizing. The stirring is continued for 2 hours after which ethyl alcohol of 95% (w/v) concentration is added to induce further crystallization. The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered with retention of a crude product, which is purified by recrystallization from boiling distilled water. The crystals are then dried at about 40°C. The free acid is then converted to the sodium salt with NaOH.

Therapeutic Function

Hepatoprotectant, Choleretic

Thiazolidine-4-carboxylic acid(444-27-9)Related Product Information

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