Butyramide Chemical Properties

Melting point:

114-116 °C

Boiling point:

216 °C

Density 

1.03

refractive index 

1.4560

FEMA 

4252 | BUTYRAMIDE

Flash point:

216°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

alcohol: soluble(lit.)

pka

16.67±0.40(Predicted)

form 

powder to crystal

color 

White to Almost white

Odor

at 100.00?%. nutty

Water Solubility 

soluble

Merck 

14,1592

JECFA Number

1593

BRN 

1361528

LogP

-0.210

CAS DataBase Reference

541-35-5(CAS DataBase Reference)

NIST Chemistry Reference

Butanamide(541-35-5)

EPA Substance Registry System

Butanamide (541-35-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29241900

Hazardous Substances Data

541-35-5(Hazardous Substances Data)

MSDS

• Language:English Provider:Butyramide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Butyramide Usage And Synthesis

Chemical Properties

Colorless to white crystalline powder or flakes with nutty aroma; soluble in water and alcohol, slightly soluble in ether.

Uses

Butyramide was used in the synthesis of hydroxamic acids, electrorheological fluids and β-amodoorganotin compounds. It was used as substrate of (+)-γ-lactamase to develop a microreactor to study enzyme stability, activity, kinetics and substrate specificity.

Definition

ChEBI: Butanamide is a monocarboxylic acid amide obtained by formal condensation of butanoic acid and ammonia. It is a primary fatty amide and a member of butanamides.

Preparation

Butyramide is prepared by amination of n-butyric acid. n-Butyric acid is heated with ammonia gas bubbled through it, and the reaction mixture reaches 200–215°C after approximately 40 hours. Heating and ammonia flow are then stopped, and the mixture is cooled below 20°C before filtration to yield butyramide.
An alternative method involves reacting n-butyric acid with urea: First, heat a mixture of 8 kg of n-butyric acid and 3 kg of urea under reflux for 10 hours. Allow the mixture to cool to 70–80°C, then add a suitable amount of hot ethanol. Decolorize the hot solution, filter it while hot, and cool. The crude product obtained by filtration is recrystallised from ethanol to yield the final product.

Aroma threshold values

Nutty type odor.

Butyramide(541-35-5)Related Product Information

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