I-CBP112 Chemical Properties

Boiling point:

623.5±55.0 °C(Predicted)

Density 

1.129±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:63.0(Max Conc. mg/mL);134.44(Max Conc. mM)
Ethanol:94.0(Max Conc. mg/mL);200.6(Max Conc. mM)
Water:94.0(Max Conc. mg/mL);200.6(Max Conc. mM)

form 

powder

pka

9.07±0.10(Predicted)

color 

white to beige

Safety Information

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

I-CBP112 Usage And Synthesis

Uses

I-CBP112 has been used in cell culture and sample preparation, to verify the acetylation of VPS34 (vacuolar protein sorting 34), by p300 at K29, K771 and K781 and to diminish synergistic gene expression.

Biochem/physiol Actions

I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please see I-CBP112 on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

+4°C