MPEG8-NH-Mal Chemical Properties

storage temp. 

-20°C

form 

solid or viscous liquid

MPEG8-NH-Mal Usage And Synthesis

Description

m-PEG8-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reactivity: thiol reactive
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: sulfhydryl reactive

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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