ChemicalBook > Product Catalog > API > Circulatory system drugs > ACE inhibitor > LCZ696 InteMediate
LCZ696 InteMediate
LCZ696 InteMediate Basic information
- Product Name:
- LCZ696 InteMediate
- Synonyms:
-
- N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester
- LCZ696 InteMediate
- (R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate
- LCZ696(valsartan + sacubitril) impurity 29
- (R) -tert-butyl (1-([1,1'-biphenyl] -4-yl) -3-hydroxypropane-2-yl) carbamate
- (R)-tert-butyl (1-([1
- 1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- CAS:
- 1426129-50-1
- MF:
- C20H25NO3
- MW:
- 327.42
- EINECS:
- 202-804-9
- Product Categories:
-
- LCZ696
- LCZ 696
- 1426129-50-1
- Mol File:
- 1426129-50-1.mol
More
Less
LCZ696 InteMediate Chemical Properties
- Boiling point:
- 514.5±50.0 °C(Predicted)
- Density
- 1.103±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.85±0.46(Predicted)
- InChI
- InChI=1S/C20H25NO3/c1-20(2,3)24-19(23)21-18(14-22)13-15-9-11-17(12-10-15)16-7-5-4-6-8-16/h4-12,18,22H,13-14H2,1-3H3,(H,21,23)/t18-/m1/s1
- InChIKey
- TYQICOFAZDVKMK-GOSISDBHSA-N
- SMILES
- C(OC(C)(C)C)(=O)N[C@@H](CO)CC1=CC=C(C2=CC=CC=C2)C=C1
More
Less
LCZ696 InteMediate Usage And Synthesis
Description
LCZ696 InteMediate is chemically known as (R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate. It is a pharmaceutical intermediate compound and a by-product in the preparation of LCZ696 (Sacubitril/valsartan). LCZ696 InteMediate can also be used to synthesize (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid.
Uses
N-?[(1R)?-?2-?[1,?1''-?Biphenyl]?-?4-?yl-?1-?(hydroxymethyl)?ethyl]?-carbamic Acid 1,?1-?Dimethylethyl Ester is a useful intermediate for preparing Sacubitril (S080900)/Valsartan (V095750).
LCZ696 InteMediateSupplier
Suzhou Sino Rare Chemical Co., Ltd. Gold
- Tel
- 0512-62857507
- sales@sinorarechem.com
hongqing Huafeng Pharmaceutical Technology Co., LTD Gold
- Tel
- 23-67950001 13883380852
- cqhfyy@foxmail.com
Shandong Sihuan Pharmaceutical Co., Ltd. Gold
- Tel
- 0531-88993893 13335127975
- fairouz@sdsihuanpharm.com
Shanghai Haoyuan Chemexpress Co., Ltd. Gold
- Tel
- 021-51870955
- info@chemexpress.com
Shaanxi Youbang Biomedical Technology Co., Ltd. Gold
- Tel
- 0913-7167565 18754046789
- 316745545@qq.com
More
Less
LCZ696 InteMediate(1426129-50-1)Related Product Information
- Sacubitril Impurity 10
- LCZ696
- LCZ Impurity
- (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one
- Sacubitril Impurity 72
- 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
- (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid
- (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
- (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one
- LCZ696 interMediate
- Valsartan
- (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
- (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
- ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester
- (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate
- AHU-377
- (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
- (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid