Flibanserin Hydrochloride Chemical Properties

Melting point:

>225°C (dec.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Pale Yellow

InChI

InChI=1S/C20H21F3N4O.ClH/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28;/h1-7,14H,8-13H2,(H,24,28);1H

InChIKey

XGAGFLQFMFCIHZ-UHFFFAOYSA-N

SMILES

C(N1C(NC2C=CC=CC1=2)=O)CN1CCN(C2C=CC=C(C(F)(F)F)C=2)CC1.Cl

Flibanserin Hydrochloride Usage And Synthesis

Uses

Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2).

Synthesis

The one-pot reaction of benzaldehyde, N-phenylhydroxylamine and trimethylcyanosilane facilitated by iodobenzene acetate first builds the important backbone benzimidazolone structure of flubanserin, and then reacts with 1,2-dibromoethane to give intermediate 8, which is then hydrolyzed in concentrated hydrochloric acid to give intermediate 9, and then finally reacts with piperazine hydrochloride10 to give flubanserin in a total yield of 29%.11 The formation of salts of flubanserin with hydrochloric acid gives flubanserin hydrochloride. Flubanserin hydrochloride is formed by salting flubanserin with hydrochloric acid. This method is characterized by low cost and easy availability of raw materials, few by-products and high yield.

Flibanserin Hydrochloride(147359-76-0)Related Product Information

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