XL999
XL999 Basic information
- Product Name:
- XL999
- Synonyms:
-
- XL999
- Tyrosine kinase-IN-1
- Tyrosine kinase inhibitor 1
- XL999;XL 999
- 2H-Indol-2-one, 5-[(1-ethyl-4-piperidinyl)amino]-3-[(3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene]-1,3-dihydro-, (3Z)-
- Tyrosine kinase IN 1,FGFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,Vascular endothelial growth factor receptor,Fibroblast growth factor receptor,inhibit,PDGFR,Tyrosine kinaseIN1
- XL-999(Tyrosine kinase-IN-1)
- (Z)-5-((1-Ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one
- CAS:
- 705946-27-6
- MF:
- C26H28FN5O
- MW:
- 445.53
- Mol File:
- 705946-27-6.mol
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XL999 Chemical Properties
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 62.5 mg/mL (140.28 mM)
- pka
- 11.67±0.20(Predicted)
- form
- Solid
- color
- Light brown to brown
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XL999 Usage And Synthesis
Uses
XL999 is a multi-target tyrosine kinase inhibitor. XL999 has IC50 values for KDR, Flt-1, FGFR1 and PDGFRα of 4 nM, 20 nM, 4 nM and 2 nM, respectively. XL999 can be used in the research of cancer[1].
in vivo
XL 999 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats[1].
IC 50
Flt-1: 4 nM (IC50); KDR: 20 nM (IC50); PDGFRα: 4 nM (IC50); FGFR1: 2 nM (IC50)
References
[1] Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985
XL999Supplier
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com