Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Organic Chemistry >  Phosphines >  Diphenylphosphinic Chloride

Diphenylphosphinic Chloride

Basic information Safety Supplier Related

Diphenylphosphinic Chloride Basic information

Product Name:
Diphenylphosphinic Chloride
Synonyms:
  • Diphenyl phosphilic chloride
  • Diphenylphoshinic
  • DIPHENYLPHOSHINIC CHLORIDE
  • Diphenylchlorophosphine oxide
  • Diphenylphosphinyl chloride,98%
  • (Chloro-phenylphosphoryl)benzene
  • Diphenylphosphinic acid chloride
  • Diphenylphosphinicchloride,98%
CAS:
1499-21-4
MF:
C12H10ClOP
MW:
236.63
EINECS:
216-107-2
Product Categories:
  • Biochemistry
  • Coupling Reactions (Peptide Synthesis)
  • Peptide Synthesis
  • Protection & Derivatization Reagents (for Synthesis)
  • Reagents for Oligosaccharide Synthesis
  • Synthetic Organic Chemistry
  • Pharmaceutical Intermediates
  • Phosphorus compounds
  • organophosphorus compound
  • Morpholines/Thiomorpholines
Mol File:
1499-21-4.mol
More
Less

Diphenylphosphinic Chloride Chemical Properties

Melting point:
20°C
Boiling point:
222 °C/16 mmHg (lit.)
Density 
1.24 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.609(lit.)
Flash point:
79 °F
storage temp. 
2-8°C
solubility 
soluble in Chloroform, methanol
form 
Liquid
Specific Gravity
1.24
color 
Clear colorless to yellow
Water Solubility 
decomposes
Sensitive 
Moisture Sensitive
BRN 
975191
CAS DataBase Reference
1499-21-4(CAS DataBase Reference)
NIST Chemistry Reference
Diphenylphosphinic chloride(1499-21-4)
More
Less

Safety Information

Hazard Codes 
C,F
Risk Statements 
10-34
Safety Statements 
16-26-36/37/39-45
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
10-21
Hazard Note 
Flammable/Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29310095

MSDS

More
Less

Diphenylphosphinic Chloride Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

Diphenylphosphinic chloride (Ph2POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.

Application

Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.

Synthesis

To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.

Diphenylphosphinic ChlorideSupplier

Shijiazhuang Benchu Technology Co., Ltd. Gold
Tel
0311-68015059 17367983103
Email
925646462@qq.com
Hubei Jusheng Technology Co.,Ltd Gold
Tel
027-59599241 18871490274
Email
1400878000@qq.com
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. Gold
Tel
15523000485
Email
xingcanyaoye@sina.com
Shaoxing Fangxiao Chemical Co., LTD Gold
Tel
13456999252
Email
shellyhouse39@126.com
CHANGZHOU HARVECHEM LTD Gold
Tel
0519-88721112
Email
supporting@harvechem.com