Dobutamine hydrochloride Chemical Properties

Melting point:

184-186 C

storage temp. 

2-8°C

solubility 

Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).

pka

9.45(at 25℃)

color 

White to Off-White

Water Solubility 

Soluble in water or ethanol with warming. Also soluble in methanol

λmax

281nm(MeOH)(lit.)

Merck 

14,3395

Stability:

Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.

CAS DataBase Reference

49745-95-1(CAS DataBase Reference)

EPA Substance Registry System

1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-63-36/37/38-R63-R62-R11-R21-R20

Safety Statements 

22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22

WGK Germany 

3

HS Code 

29222990

Toxicity

LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)

MSDS

• Language:English Provider:SigmaAldrich

Dobutamine hydrochloride Usage And Synthesis

Description

Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.

Chemical Properties

Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.

Uses

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.

Uses

Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.

Definition

ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.

brand name

Dobutrex (Lilly）.

Biological Activity

β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Pharmacokinetics

Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.

Veterinary Drugs and Treatments

Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.

storage

Desiccate at RT

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